Estrogen-Dependent and -Independent Estrogen Receptor-α Signaling Separately Regulate Male Fertility
نویسندگان
چکیده
منابع مشابه
Significance of microRNA targeted estrogen receptor in male fertility
Objective(s): Estrogen receptor-alpha (ERα) mediates estrogen action in regulation of different levels of the hypothalamic-pituitary-testis axis. It has a key role in spermatogenesis. Estrogen receptor alpha knock-out (ER koα) male mice were infertile and severe impairment in spermatogenesis and seminiferous tubules was observed. Recently, it has been reported that microRNA (miRNA) mir-100 and ...
متن کاملsignificance of microrna targeted estrogen receptor in male fertility
objective(s): estrogen receptor-alpha (erα) mediates estrogen action in regulation of different levels of the hypothalamic-pituitary-testis axis. it has a key role in spermatogenesis. estrogen receptor alpha knock-out (er koα) male mice were infertile and severe impairment in spermatogenesis and seminiferous tubules was observed. recently, it has been reported that microrna (mirna) mir-100 and ...
متن کاملSignificance of microRNA targeted estrogen receptor in male fertility
OBJECTIVE(S) Estrogen receptor-alpha (ERα) mediates estrogen action in regulation of different levels of the hypothalamic-pituitary-testis axis. It has a key role in spermatogenesis. Estrogen receptor alpha knock-out (ER koα) male mice were infertile and severe impairment in spermatogenesis and seminiferous tubules was observed. Recently, it has been reported that microRNA (miRNA) mir-100 and l...
متن کاملEstrogen-related Receptor β Reduces the Subnuclear Mobility of Estrogen Receptor α and Suppresses Estrogen-dependent Cellular Function.
Estrogen-related receptor (ERR) is a member of the nuclear receptor superfamily that has strong homology with estrogen receptor (ER) α. ERR has three subtypes (α, β, and γ) expressed in estrogen-sensitive organs, including ovary, breast, and brain. No endogenous ligands of ERRs have been identified, but these receptors share a common DNA element with ERα and control estrogen-mediated gene trans...
متن کاملMolecular mechanism of estrogen–estrogen receptor signaling
17β-Estradiol (E2), as the main circulating estrogen hormone, regulates many tissue and organ functions in physiology. The effects of E2 on cells are mediated by the transcription factors and estrogen receptor (ER)α and ERβ that are encoded by distinct genes. Localized at the peri-membrane, mitochondria, and the nucleus of cells that are dependent on estrogen target tissues, the ERs share simil...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2009
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2008-1016